Anti-SEL1L adaptor subunit of ERAD E3 ubiquitin ligase antibodies are used for the immunodetection of the protein encoded by the SEL1L gene. In humans, the canonical protein has a reported length of 794 amino acid residues and a mass of 88.8 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be highly expressed in the pancreas. A member of the Sel-1 protein family, it is reported to play a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Post-translational modifications have been described, including N-glycosylation. Other names for this target antigen include PRO1063, SEL1-LIKE, SEL1L1, protein sel-1 homolog 1, SEL1L, ERAD E3 ligase adaptor subunit, and Hrd3. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.