Anti-isocitrate dehydrogenase (NADP(+)) 1 antibodies are used for the immunodetection of the protein encoded by the IDH1 gene. In humans, the canonical protein has a reported length of 414 amino acid residues and a mass of 46.7 kDa. Its subcellular localization is in the cytoplasm. A member of the Isocitrate and isopropylmalate dehydrogenases protein family, it is known to catalyze the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Post-translational modifications have been described, including acetylation. The gene encoding this protein is implicated in Glioma. Other names for this target antigen include HEL-S-26, IDCD, IDH, IDP, IDPC, PICD, isocitrate dehydrogenase [NADP] cytoplasmic, and HEL-216. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.