Anti-WRN RecQ like helicase antibodies are used for the immunodetection of the protein encoded by the WRN gene. In humans, the canonical protein has a reported length of 1432 amino acid residues and a mass of 162.5 kDa. Its subcellular localization is in the nucleus. A member of the Helicase protein family, it is reported to be a multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Post-translational modifications have been described, including phosphorylation. The gene encoding this protein is implicated in Werner syndrome. Other names for this target antigen include RECQL2, RECQL3, bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, DNA helicase, RecQ-like type 3, Werner syndrome ATP-dependent helicase, and RECQ3. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.