Anti-alkaline phosphatase, biomineralization associated antibodies are used for the immunodetection of the protein encoded by the ALPL gene. In humans, the canonical protein has a reported length of 524 amino acid residues and a mass of 57.3 kDa. Its subcellular localization is in the mitochondria and cell membrane. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Alkaline phosphatase protein family, it is reported to be an alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis. Post-translational modifications have been described, including N-glycosylation. The gene encoding this protein is implicated in Hypophosphatasia. Other names for this target antigen include APTNAP, HOPS, HPPA, HPPC, HPPI, HPPO, TNALP, and AP-TNAP. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.