Anti-WT1 transcription factor antibodies are used for the immunodetection of the protein encoded by the WT1 gene. In humans, the canonical protein has a reported length of 449 amino acid residues and a mass of 49.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be expressed in the kidney and a subset of hematopoietic cells. A member of the EGR C2H2-type zinc-finger protein family, it is reported to be a transcription factor that plays an important role in cellular development and cell survival. The gene encoding this protein is implicated in Frasier syndrome. Other names for this target antigen include GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor protein, Wilms tumor 1, and AWT1. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.