Anti-MAD2L1 antibodies are used in the immunodetection of the protein mitotic arrest deficient 2 like 1. In humans, the canonical protein has a reported length of 205 amino acid residues and a mass of 23.5 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of a the MAD2 protein family, MAD2L1 is a known component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include MAD2, MAD2 (mitotic arrest deficient, yeast, homolog)-like 1, MAD2 mitotic arrest deficient-like 1, and HSMAD2.