Anti-PR/SET domain 8 antibodies are used for the immunodetection of the protein encoded by the PRDM8 gene. In humans, the canonical protein has a reported length of 689 amino acid residues and a mass of 71.7 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in the brain, heart, skeletal muscle, testes, prostate. A member of the Class V-like SAM-binding methyltransferase protein superfamily, it is a suspected histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity).
The PR/SET domain 8 marker can be used to characterize Medial Excitatory Neurons.* Other names for this target antigen include PR domain 8, PR-domain containing protein 8, and PR domain zinc finger protein 8. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some PR/SET domain 8 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4