Anti-LRIG1 antibodies are used in the immunodetection of the protein leucine rich repeats and immunoglobulin like domains 1. In humans, the canonical protein has a reported length of 1093 amino acid residues and a mass of 119.1 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is widely expressed across many tissue types. LRIG1 is known to act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
The LRIG1 marker can be used to identify Cells Large Intestine Intestinal Crypt Stem Cells.* Synonyms for this target antigen include LIG1, leucine-rich repeats and immunoglobulin-like domains protein 1, leucine-rich repeat protein LRIG1, ortholog of mouse integral membrane glycoprotein LIG-1, and LIG-1. LRIG1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 50 citations in the literature describe the use of LRIG1 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4