Anti-COL1A1 antibodies are used in the immunodetection of the protein collagen type I alpha 1 chain. In humans, the canonical protein has a reported length of 1464 amino acid residues and a mass of 138.9 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is notably widely expressed in many tissue types. A member of the Fibrillar collagen protein family, COL1A1 is known to be involved with blood vessel development and TNF-mediated cellular signaling pathways. Post-translational modifications have been described, including O-glycosylation. The COL1A1 marker can be used to identify Fibroblasts, Myofibroblasts, Myofibroblast Cells, and Type 2 Thymic Fibroblasts.* Synonyms for this target antigen include EDSARTH1, EDSC, OI1, OI2, OI3, OI4, collagen alpha-1(I) chain, and CAFYD. COL1A1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4