Anti-ADAMTS like 1 antibodies are used for the immunodetection of the protein encoded by the ADAMTSL1 gene. In humans, the canonical protein has a reported length of 1762 amino acid residues and a mass of 193.4 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Alternative splicing is reported to yield 6 different isoforms for this protein. It is notably expressed in adult skeletal muscle. It is noted to be involved in extracellular matrix organization. Post-translational modifications have been described, including O-glycosylation and N-glycosylation.
The ADAMTS like 1 marker can be used to characterize Deep-Layer Corticothalamic And 6B Neurons, Eccentric Medium Spiny Neurons, Cerebral Cortex MGE Interneurons, and Medulla Oblongata Splatter Neurons.* Other names for this target antigen include ADAM-TS related protein 1, punctin-1, and ADAMTS-like protein 1. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some ADAMTS like 1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4