Anti-estrogen receptor 2 antibodies are used for the immunodetection of the protein encoded by the ESR2 gene. In humans, the canonical protein has a reported length of 530 amino acid residues and a mass of 59.2 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 9 different isoforms for this protein. A member of the Nuclear hormone receptor protein family, it is known to be involved with cell to cell signaling and the regulation of cell growth.
The estrogen receptor 2 marker can be used to characterize Placental Microvascular Endothelial Cells.* Other names for this target antigen include ESR-BETA, ESRB, ESTRB, Erb, NR3A2, ODG8, estrogen receptor beta, and ER-BETA. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 650 citations in the literature describe the use of estrogen receptor 2 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4