Anti-MDM2 proto-oncogene antibodies are used for the immunodetection of the protein encoded by the MDM2 gene. In humans, the canonical protein has a reported length of 491 amino acid residues and a mass of 55.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 11 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the MDM2/MDM4 protein family, it is known to be involved with the apoptotic pathway and blood vessel development. Other names for this target antigen include HDMX, LSKB, hdm2, E3 ubiquitin-protein ligase Mdm2, MDM2 oncogene, E3 ubiquitin protein ligase, and ACTFS. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 540 citations in the literature describe the use of MDM2 proto-oncogene antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.