Anti-USB1 antibodies are used in the immunodetection of the protein U6 snRNA biogenesis phosphodiesterase 1. In humans, the canonical protein has a reported length of 265 amino acid residues and a mass of 30.3 kDa. Its subcellular localization is in the nucleus. Up to 3 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the adrenal gland, thyroid gland, and adipose tissue. A member of the USB1 protein family, USB1 is known to be involved with RNA splicing. The USB1 gene has been associated with the disease, Poikiloderma with neutropenia. Synonyms for this target antigen include 3'-5' RNA exonuclease USB1, HVSL motif containing 1, U six biogenesis 1, U6 snRNA biogenesis 1, U6 snRNA phosphodiesterase, and U6 snRNA phosphodiesterase 1. USB1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some USB1 antibodies may have been used in research and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.