Anti-MGP antibodies are used in the immunodetection of the protein matrix Gla protein. In humans, the canonical protein has a reported length of 103 amino acid residues and a mass of 12.4 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is notably expressed in soft tissue, prostate, and cartilage. A member of the Osteocalcin/matrix Gla protein family, MGP is reported to associate with the organic matrix of bone and cartilage.
The MGP marker can be used to identify Brain Vascular Non-Neuronal Cells, Pericytes, and Type 2 Thymic Fibroblasts.* Synonyms for this target antigen include MGLAP, NTI, cell growth-inhibiting gene 36 protein, and GIG36. MGP gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of MGP antibodies have been mentioned in research publications and have associated citations. Western Blot and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4