Anti-Argininosuccinate Lyase antibodies are used for the immunodetection of the protein encoded by the ASL gene. In humans, the canonical protein has a reported length of 464 amino acid residues and a mass of 51.7 kDa. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the Lyase 1 protein family, it is known to catalyze the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Post-translational modifications have been described, including acetylation. The gene encoding this protein is implicated in Argininosuccinic aciduria. Other names for this target antigen include argininosuccinase, arginosuccinase, and ASAL. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.