Anti-ACTN3 antibodies are used in the immunodetection of the protein actinin alpha 3. In humans, the canonical protein has a reported length of 901 amino acid residues and a mass of 103.2 kDa. It is found to be preferentially expressed in a subset of type 2 skeletal muscle fibers. A member of the Alpha-actinin protein family, ACTN3 is known to be involved with cytoskeleton organization and carbohydrate metabolism and homeostasis. Synonyms for this target antigen include alpha-actinin-3, F-actin cross-linking protein, alpha-actinin skeletal muscle, and ACTN3D. ACTN3 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. Over 280 citations in the literature describe the use of ACTN3 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.