Anti-NFIX antibodies are used in the immunodetection of the protein nuclear factor I X. In humans, the canonical protein has a reported length of 502 amino acid residues and a mass of 55.1 kDa. Its subcellular localization is in the nucleus. Up to 6 different isoforms have been reported for this protein. It is widely expressed across many tissue types. A member of the CTF/NF-I protein family, NFIX is known to recognize and bind the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. The NFIX marker can be used to identify Ventral Inhibitory Neurons and Medial Excitatory Neurons.* Synonyms for this target antigen include MALNS, MRSHSS, NF1-X, NF1A, SOTOS2, nuclear factor 1 X-type, CCAAT-box-binding transcription factor, and CTF. NFIX gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4