Anti-PDGFD antibodies are used in the immunodetection of the protein platelet derived growth factor D. In humans, the canonical protein has a reported length of 370 amino acid residues and a mass of 42.8 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is notably expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in the placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. A member of the PDGF/VEGF growth factor protein family, PDGFD is reported to be a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.
The PDGFD marker can be used to identify Upper-Layer Intratelencephalic Neurons, Brain Splatter Neurons, Gray Matter Chandelier Neurons, and Hypothalamus Splatter Neurons.* Synonyms for this target antigen include iris-expressed growth factor and spinal cord-derived growth factor B. PDGFD gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PDGFD antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4