Anti-HLA-DQA1 Antibody Products

Anti-HLA-DQA1 antibodies are used in the immunodetection of the protein major histocompatibility complex, class II, DQ alpha 1. In humans, the canonical protein has a reported length of 254 amino acid residues and a mass of 27.8 kDa. Its subcellular localization is in the ER, Golgi, lysosomes, and cell membrane. It is notably expressed in many tissues, such as the adrenal gland and endometrium. A member of the MHC class II protein family, HLA-DQA1 is known to bind peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells.

The HLA-DQA1 marker can be used to identify Unswitched Memory B Cells, Class Switched Memory B Cells, CD8?- Thymic Conventional Dendritic Cells, and Type 2 Medullary Thymic Epithelial Cells.* Synonyms for this target antigen include DQ-A1, DQA1, HLA-DQA, HLA-DQA1*, HLA-DQB1, and CELIAC1. HLA-DQA1 gene orthologs have been reported in the mouse species. Over 270 citations in the literature describe the use of HLA-DQA1 antibodies in research. Flow Cytometry is a widely used application for these antibodies. ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry are also common applications.