Santa Cruz Biotechnology, Inc.
p38 antibody
sc-7973
D-8
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Nongenomic signalingby estrogens, including rapid changes of mitogen-activated protein(MAP) kinase and other signal-transduction-cascades activity, has been proposed to be essential for the mitogenic actions of these hormones and their nuclear receptors. Because regulation of gene transcription is considered a key step in cell cycle control by mitogenic protein kinase cascades, here we investigated the possibility that estrogen might induce the activation of extracellular signal-regulated kinase (Erk) 1/2-, c-Jun NH2-terminal kinase-, p38- or protein kinase A-responsive transcription factors in the cell nucleus during stimulation of early G1 progression, a timing coincident with the maximum effects of these hormones on such enzyme activity.
Western Blot
Cell lysate
1:1000 dilution in 5% skim milk prepared in 1x TBST
5% skim milk
1:4000 5% milk
None
ECL
HBC and other cell types, estrogens and ERs have been shown to stimulate adenylate cyclase and cAMP-dependent signaling (9) , to induce activation of p38 , and to prevent activation of Jnk MAP kinases. It is not clear at present how the above-mentioned genomic and nongenomic pathways of estrogen action integrate each other to achieve the full cellular response to the hormone and how these kinase cascades contribute to activation of cell cycle gene networks by estrogen in stimulated cells.
N/A
No background and strong signal
HBC and other cell types, estrogens and ERs have been shown to stimulate adenylate cyclase and cAMP-dependent signaling (9) , to induce activation of p38 .