Cayman
1-Deoxymannojirimycin (hydrochloride)
17178
Info: View 1-Deoxymannojirimycin Products
1-DMJ and Tunicamycin were compared for the ability to prevent N-glycosylation in mammalian cells. Both worked at 25 nM; however, only 1-DMJ was non-toxic.
Cell proliferation and flow cytometry
Human breast cancer cells
Product was first tested and shown to be non-toxic up to 20 µM. Then it was used at 25 nM to prevent protein N-glycsoylation as measured by flow cytometry.
Far superior to tunicamycin
Results demonstrated that 1-DMJ was non-toxic in human cells up to 20 µM. High concentrations were not tested. It was then an efficient glycosylation inhibitor at 25 nM.
N/A
Non-toxic and effective at low concentrations
None
Works far better than tunicamycin to prevent N-glycosylation