Tocris Bioscience
Pertussis Toxin
3097/50U
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GPCR plays important role in LPA-mediated COX-2 activation.
Cell culture
MG-63 cells
MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot.
N/A
Pertussis Toxin inhibited COX-2 expression induced by LPA.
Worked as expected
Pertussis Toxin can be used to inhibit GPCR signaling.