Tocris Bioscience
KN 92
4130/1
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CaMKII regulates cardiac ion channels contributing action potential. To understand this process in detail we use KN93, a CaMKII inhibitor, and KN92, an inactive homolog of KN93.
Cell culture
Guinea pig ventricular cardiomyocytes
Guinea pig ventricular cardiomyocytes were treated (12-16 h) with KN93 (5 µM), KN92 (5 µM) or Ranolazine (10 µM). Cells were patched and stimulated at a 1 Hz frequency to record action potential.
N/A
Maximum upstroke velocity was significantly was reduced by KN93 while KN92 was ineffective.
Worked as expected
KN92 does not have any effect on cardiac action potential upstroke velocity.