Tocris Bioscience
KN 93 phosphate
5215/1
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CaMKII regulates cardiac ion channels contributing action potential. To understand this process in detail we use KN93, a CaMKII inhibitor, and KN92, an inactive homolog of KN93.
Cell culture
Guinea pig ventricular cardiomyocytes
Guinea pig ventricular cardiomyocytes were incubated with KN93 phosphate (5 µM, 30 min) prior to HOCl-LDL (250 µg/ml, 14 h) addition followed by loading of cells with Fura-2AM.
N/A
Cells were stimulated at a 1 Hz frequency and Ca2+ transient (CaT) amplitude was analyzed. KN93 phosphate significantly inhibited HOCl-LDL-reduced CaT amplitude
Worked as expected
KN92 does not have any effect on cardiac action potential upstroke velocity.