KN93 Ameliorates HOCl-LDL-Reduced ICa,L Density in Cardiomyocytes

July 08, 2019

Medical University of Graz
Division of Cardiology
Lab Technician

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Company:

Tocris Bioscience

Product Name:

KN 93

Catalog Number:

1278/1

CaMKII regulates cardiac L-type calcium channel activity.

Experimental Design and Results Summary

Application

Cell culture

Starting Material

Guinea pig ventricular cardiomyocytes

Protocol Overview

Guinea pig ventricular cardiomyocytes were treated with HOCl-LDL (250 µg/ml, 12-16 h)in the absence or presence of KN93 (5 µM) to follow L-type Ca2+ current (ICa,L) using patch clamp analysis.

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Results Summary

KN93 ameliorated HOCl-LDL-reduced ICa,L density.

DOI or PMID #

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Additional Notes

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Summary

The Good

Works as expected

The Bad

N/A

The Bottom Line

KN93 can be used to understand CaMKII effects on L-type calcium channel activity.

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