Tocris Bioscience
Phorbol 12,13-dibutyrate
4153/1
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Guinea pig ventricular cardiomyocytes were patched and superfused with Saxagliptin (2 µM, 5 min) followed by Phorbol 12,13-dibutyrate (PDB, 10 nM, 5 min) and action potentials were stimulated at a 1 Hz frequency. Action potential duration (APD) were analysed at 20%, 50%, and 90% repolarization (shown in Image). PDB reduced saxagliptin-induced APD prolongation.
Cardiac electrophysiology
Primary ventricular cardiomyocytes
Guinea pig ventricular cardiomyocytes were patched and superfused with Saxagliptin (2 µM, 5 min) followed by Phorbol 12,13-dibutyrate (PDB, 10 nM, 5 min) and action potentials were stimulated at a 1 Hz frequency.
N/A
Action potential duration (APD) were analysed at 20%, 50% and 90% repolarization (shown in Image). PDB reduced saxagliptin-induced APD prolongation.
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PDB reduces saxagliptin-induced APD prolongation in cardiomyocytes.