Tocris Bioscience
Ranolazine dihydrochloride
3118/50
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Guinea pig ventricular cardiomyocytes were treated (12–16 hr) with HOCl-LDL (250 µg/ml). Cells were patched and stimulated at a frequency of 1 Hz. Representative action potentials (shown in Image) recorded in the same cell are shown before (A) and after (B) superfusion with Ranolazine (10 µM, 5 min). For comparative purpose representative APs of a control cardiomyocyte are shown (C).
Cardiac electrophysiology
Primary ventricular cardiomyocytes
Guinea pig ventricular cardiomyocytes were treated (12–16 hr) with HOCl-LDL (250 µg/ml). Cells were patched and stimulated at a frequency of 1 Hz followed by superfusion with Ranolazine (10 µM, 5 min).
N/A
Ranolazine superfusion for 5 min resulted in reversal of arrhythmic events induced by HOCl-LDL in cardiomyocytes.
Works as expected
Reversal of HOCl-LDL induced arrhythmia by ranolazine superfusion