The Good
The Surf-Blot System is without a doubt the simplest and most effective means to perform immunoblots with multiple primary antibodies or serum specimens simultaneously.
The Bad
Although the Surf-Blot System permits experiments to be carried out that would otherwise be very difficult if not impossible, assembly, disassembly, and cleaning the apparatus is a bit cumbersome. This is especially evident when optimizing for different primary antibodies when several runs may be required. Also, only one secondary antibody can be used on the resulting blot, unless the blot is cut after incubation with primary antibody.
The Bottom Line
This is a very useful and economical piece of equipment. Given the care needed to use the apparatus successfully, it may be best to appoint someone to be the Surf-Blot guru rather than have everyone in the lab using it.