Genotyping technologies provide a powerful toolset for examining the widest range of genetic variation. Human genetic variation is present in many different forms in the genome, ranging from large, structural, chromosomal changes to single nucleotide polymorphisms (SNPs). There exists a broad range of products for analysis of genetic variation and genomic profiling. Traditional methods include in situ hybridization, SNP genotyping, AFLP and microsatellite analysis; real-time PCR-based methods using TaqMan® Assays. Whereas more advanced genomic profiling techniques continue to develop, such as array comparative genomic hybridization. Genotyping is a key tool in the research of gene variants associated with disease. Genotyping technologies have brought understanding to the meaning and consequences of the incredible amount of variation in genomic DNA and its transcription products.
Mutations are changes in DNA sequence and are the cause of genetic variation and...
The assay analyzes the C-to-T mutation occurring at nucleotide 677 of the gene ...
Thursday, November 14, 2013
Typical next-generation sequencing protocols, for example, call for microgram quantities of starting...
Tuesday, September 10, 2013
Many labs conduct genome-scale SNP analyses -- these are the headline-grabbing “genome-wide ...
Wednesday, November 30, 2011
Comparative Analysis of Genome-Wide Copy Number Variation Detection in Humans using High-Resolution Array Platforms
Watch Video: The Infinium® HD FFPE Restoration Solution
Thursday, February 17, 2011
Roche Applied Science: Exome Sequencing of Multigenerational Mendelian Families