Articles in this Issue

• Kinases as Targets for Drug Discovery in an Academic Setting

  William P. Janzen, Emily A. Hull-Ryde
  Imaging technologies permits researchers to gather more data from each animal. In some cases, use of these techniques can permit reduction of the overall numbers of animals needed. Traditional xenograft studies use physical measurement of tumor size.... read more

• qPCR Roundtable

  Philip J. Day, Ph.D., Dr. Michael W. Pfaffl, Dr. Annette Tietze, Ph.D., Aleš Tichopád, Ph.D. (*AT), Mikael Kubista, Prof., Dr. Frank McCaughan
  qPCR is moving into a new realm for nucleic acid analyses in that the process is being entrusted to absolute quantification of nucleic acids. read more

• Molecular Imaging of Cancer: Prediction and Early Detection of Response by NMR Spectroscopy...

  Seung-Cheol Lee, Harish Poptani, E. James Delikatny, Mariusz Wasik, Michal Mar-cek, Stephen J. Schuster, Sunita D. Nasta, Jakub Svoboda, Steven C. Goldstein, Fer-nando Arias-Mendoza, Jerry D. Glickson
  Systemic therapy (chemotherapy, immunotherapy and radio-immunotherapy) of cancer is currently administered according to statistically based protocols developed through standardized random clinical trials with the choice of treatment read more

• The Application of Label-free Technologies in Drug Discovery for Soluble Protein Targets

  Sheraz Gul, Ph.D.
  A vast number of technologies are currently available for the development of assays for soluble protein targets that are high throughput screening compatible. These assays are usually developed in microtitre plate format so that large numbers of ... read more

• New Approaches for the Development of Nucleic Acid-based Therapeutics: Challenges and Opportunities...

  Marina A. Zenkova, Dmitrii V. Pyshnyi, Waleed A. Zalloum, Mengisteab B. Gebrezgiabher, Elena V. Bichenkova
  This article presents a brief overview of both existing and new, emerging strategies for RNA-mediated gene silencing that can potentially be applied as highly selective approaches against abnormal gene expression. Despite the availability of numerous... read more

• HCA of Complex Cell Models for Single Agent and Combination Studies of Drug Efficacy

  Beverley Isherwood, Ph.D.
  Lack of efficacy is a significant cause of late-stage failure in drug discovery, hence, the importance placed on strategies to better predict efficacy earlier. Critical to this objective is the use of pathophysiologically relevant models of disease ... read more