Editorial Articles

  • Amplification Enumeration: dPCR or qPCR?

    dPCR vs. qPCR

    Thursday, February 19, 2015
    Both qPCR and dPCR have their place, with a large overlap between them. Here we look at some reasons, besides history and existing infrastructure, a ... read more
  • Detecting Circulating Tumor Cells

    Detecting Circulating Tumor Cells

    Monday, January 19, 2015
    Oncologists traditionally rely on invasive biopsies and non-invasive imaging modalities to track tumor size and spread. Circulating tumor cells (CTCs)... read more
  • Bioinformatics Tools for lncRNA Research

    Bioinformatics Tools for lncRNA

    Friday, November 14, 2014
    Researchers increasing recognize the functional importance of long noncoding RNAs, and for the most part, the tools to study them already are in place... read more
  • Squeeze More Data from Your Sample with Multiplexed qPCR

    Multiplex qPCR

    Tuesday, April 15, 2014
    Multiplex qPCR commonly used for SNP detection, gene expression and other applications for which a large number of samples, or precious samples, need ... read more
  • Chromosomal Translocations and the Hunt for Cancer Biomarkers

    Finding Cancer Biomarkers

    Tuesday, April 01, 2014
    Cancer researchers are constantly on the lookout for ways to predict disease outcome, determine which therapies are called for and track patient ... read more
  • Gene Expression Analysis Tools for Non-Model Organisms

    Gene Expression Analysis

    Thursday, February 27, 2014
    Using next-generation DNA sequencing, cloud computing and in silico design tools, anyone can become expert in the gene expression of organisms outside... read more
  • No NGS, No Problem. Outsource Your Analyses with These MicroRNA Service Providers

    Outsourcing miRNA Analysis

    Tuesday, February 18, 2014
    For many researchers, microRNA discovery and investigation are more a means to an end than the focus of their research. Or perhaps they simply are ... read more
  • Probe Noncoding RNA Biology with Protein-lncRNA Interaction Tools

    Probing Protein-lncRNA Interactions

    Tuesday, November 19, 2013
    There is considerable research interest in the class of molecules called long noncoding RNAs (lncRNAs). Many have been identified, but few have had ... read more
  • FISHing for Accurate Transcript Counts with Single-Molecule FISH

    Transcript Counting with smFISH

    Tuesday, October 29, 2013
    In its traditional incarnation, FISH is qualitative: Cells are either positive or negative for a given nucleic acid. But single-molecule quantitative ... read more
  • Bioinformatics Tools for Gene Expression: Crunching the Numbers

    Software Tools for Gene Expression Analysis

    Thursday, October 24, 2013
    Gene-expression studies yield multitudes of data, and turning those data into biological insights requires software. A variety of options are ... read more
  • Tips for Choosing a qPCR Instrument

    Choosing a qPCR Instrument

    Thursday, September 26, 2013
    qPCR is used for measuring RNA abundance, quantifying pathogen loads and validating microarray and sequencing data, among other applications. First, ... read more
  • RNA Purification: Making the Most of Difficult Samples

    RNA Prep from Problem Samples

    Thursday, August 22, 2013
    Expression analysis has become commonplace. First, though, you need to harvest the RNA. Here are tips for making the most of some difficult sample ... read more
  • Of Noncoding RNA and Epigenetics

    Of Noncoding RNA and Epigenetics

    Tuesday, July 23, 2013
    Whether long, small or micro, noncoding RNAs are not translated into proteins, yet fulfill important regulatory roles in gene expression. Here we ... read more
  • Four Keys to Selecting the Right PCR Machine

    Buyers' Guide to Thermal Cyclers

    Monday, July 15, 2013
    In the market for a PCR instrument? Here are four variables to consider. read more
  • Detecting Copy-Number Variation at High Resolution

    High-res CNV Detection

    Thursday, June 13, 2013
    Traditionally, geneticists identified CNVs using fluorescence in situ hybridization (FISH) and early microarrays, but those methods had limited ... read more
  • Transcriptome Analysis: Microarrays, qPCR and RNA-Seq

    Transcriptome Tools

    Tuesday, May 21, 2013
    Transcriptomics studies attempt to catalog and quantify the RNA content of a cell, tissue or organism. There essentially are three techniques for ... read more