Fig 1: Effects of telmisartan low and high doses as standard drug (TL, TH) and as SNEDDS formula (TLS, THS) on plasma levels of ALT and AST in TAA-induced hepatic fibrosis rats (n = 8). Data are expressed as mean ± SEM. *: P < 0.05 vs. Normal control (NC), #: P < 0.05 vs. Positive control (PC) and TL, ^: P < 0.05 vs. TH & TLS.
Fig 2: (A) Aspartate transaminase (AST) levels in u/l, (B) Alanine aminotransferase (ALT) in u/l, (C) Alkaline phosphatase (ALP) in unit/liter (u/l), and (D) lactate dehydrogenase (LDH) (IU/L), were measured in the control rats, rats injected with vancomycin only, and rats injected with vancomycin and resveratrol. Significant difference: ns = non-significant, **p < 0.001 ****p < 0.0001.
Fig 3: Effect of URO A on serum biomarkers of hepatotoxicity induced by DOX in rats: (A) AST activity, (B) ALT activity, and (C) GGT activity. Data are presented as mean ± SEM (n = 6); * indicates significantly different at p < 0.05 and **** at p < 0.0001; ns: nonsignificant.
Fig 4: Comparison of ALT (IU/L) in different studied groups at 1st and 12th weeks. *: significance versus control. #: significance versus Vit D &: significance versus MetS. *: P < 0.050, **: P < 0.010, ***: P < 0.001.
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