Fig 2: A positive correlation was observed between CD133 and CD82 mRNA expression in pediatric B cell-acute lymphoblastic leukemia. CD, cluster of differentiation.

Fig 3: Relevance between CD34+CD133+ and CD34+CD82+ cell frequency and CD133 and CD82 mRNA expression in pediatric patients with acute lymphoblastic leukemia. (A) A positive correlation was observed between the percentage of CD34+CD82+ cells and CD82 mRNA expression. (B) A positive correlation was observed between the percentage of CD34+CD133+ cells and CD133 mRNA expression. CD, cluster of differentiation.

Fig 4: Frequency of CD34+, CD34+CD82+ and CD34+CD133+ cells in patients with ALL-ND and controls. (A) Frequency of CD34-positive cells in patients with ALL-ND was significantly increased compared with controls. (B) Frequency of CD34+CD82+ cells in patients with ALL-ND was significantly higher than in controls. (C) In 6 of 17 patients with ALL-ND, the frequency of CD34+CD133+ cells was >10%, whereas no control patients exhibited a frequency of CD34+CD133+ cells of 10%. CD, cluster of differentiation; ALL-ND, newly diagnosed acute lymphoblastic leukemia. **P<0.001 vs. controls.

Fig 5: mRNA expression of CD133 and CD82. (A) CD82 mRNA expression in ND was significantly higher than in controls. **P<0.001, ND vs. control (B) CD82 mRNA expression in B-ALL ND was significantly higher than in CR and controls. *P<0.05, ND vs. CR or ND vs. control (C) CD82 mRNA expression in T-ALL ND and CR was significantly higher than in controls. *P<0.05, ND vs. control or CR vs. control (D) CD133 mRNA expression was markedly higher in B-ALL ND compared with controls, and CD133 mRNA expression was significantly higher than in CR. *P<0.05, ND vs. CR. ND, newly-diagnosed; CR, complete remission; CD, cluster of differentiation; B-ALL, B cell-acute lymphoblastic leukemia; T-ALL, T cell-acute lymphoblastic leukemia.