Description
Product Characteristics:
ABTB1 is a 478 amino acid protein localized to the cytoplasm. ABTB1 contains two ANK repeats and two BTB (POZ) domains. The BTB (POZ) domain is thought to be involved in protein-protein interactions, and may indicate a role of ABTB1 in developmental processes. It has also been suggested that ABTB1 may be a mediator of the PTEN growth-suppressive signaling pathway. ABTB1 is ubiquitously expressed in all fetal tissues, with lower levels of expression found in adult heart. ABTB1 exists as four isoforms produced by alternative splicing.
Subcellular location: Cytoplasm
Synonyms: ABTB 1, ABTB1, ABTB1_HUMAN, Ankyrin repeat and BTB POZ domain containing 1, Ankyrin repeat and BTB/POZ domain containing 1, Ankyrin repeat and BTB/POZ domain containing protein 1, Ankyrin repeat and BTB/POZ domain-containing protein 1, EF1ABP, Elongation factor 1A binding protein, Elongation factor 1A-binding protein, MGC20585, PP 2259, PP2259.
Target Information: This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]