Description
Product Characteristics:
May mediate microtubule plus end-directed vesicle transport.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: CATC2, RUFY3, ZFYVE7, CTRCT18, FYVE and coiled-coil domain-containing protein 1, Zinc finger FYVE domain-containing protein 7, FYCO1
Target Information: This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]