Description
Product Characteristics:
Puromycin-sensitive aminopeptidase is a 100 kDa zinc metallopeptidase which degrades neuropeptides by removing amino acid residues from the amino-terminus. The protein is the most abundant aminopeptidase in the brain, however it is not exclusive to that organ. It is localized primarily in the cytoplasm, and plays a role in the metabolism of neuropeptides in nerve terminals and synaptic clefts. The human PSA gene maps to chromosome 17q 2-32.
Subcellular location: Cytoplasm
Synonyms: AAP-S,aminopeptidase puromycin sensitive,Cytosol alanyl aminopeptidase,METALLOPROTEASE 100,METALLOPROTEASE MP100,MP 100,MP100,Npepps,PSA,PSA_HUMAN,Puromycin sensitive aminopeptidase,Puromycin-sensitive aminopeptidase.
Target Information: This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]