Description
Product Characteristics:
MP21 is a member of the EMP24/GP25L/p24 cargo family of proteins that regulates vesicular trafficking in the early secretory pathway. TMP21 is a ubiquitously expressed single-pass type I membrane protein localizing to the Golgi cisternae and the plasma membrane. It contains one GOLD (Golgi dynamics) domain and participates in protein transport and quality control between the endoplasmic reticulum (ER) and the Golgi complex. In addition, TMP21 is a component of the heteromeric secretase complex (or Presenilin complex) and functions to regulate the ?secretase activity. Two isoforms, namely TMP21-I and TMP21-II, exist for this protein.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: p23, p24 family protein delta 1, p24delta, p24delta1, S31I125, S31III125, TMED 10, TMED10, Tmp 21 I, Tmp 21, Tmp 21 I, Transmembrane emp24 domain containing protein 10, Transmembrane emp24-like trafficking protein 10 yeast, Transmembrane protein Tmp21, Transmembrane trafficking protein 21kD, 1110014C03Rik, 21 kDa transmembrane trafficking protein, MGC102351, TMEDA_HUMAN.
Target Information: This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]