Description
Product Characteristics:
The membranes of myelinating Schwann cells are joined by tight, gap and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman and mesaxons. Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Pals-associated tight junction protein (PATJ), the human homolog of Drosophila Discs Lost, is differentially localized in myelinating Schwann cells. PATJ associates with Claudin-1, CRB1 (a transmembrane protein that plays a role in epithelial cell polarity and photoreceptor development), and Pals1 (a Lin-7 associated protein). The PATJ/Pals1/CRB1 complex can form a tripartite tight junction in epithelial cells crucial to their integrity.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Channel interacting PDZ domain protein, Cipp, FLJ26982, hINADL, Inactivation no after potential D like protein, INAD like, InaD like Drosophila, INAD like protein, INADL, INADL protein, PALS 1 associated tight junction protein, PALS1 associated tight junction protein, PATJ, PDZ domain protein, PDZ domain protein Drosophila inaD like, Post synaptic density 95 / discs large / zonula occludens 1 domain protein, Protein associated to tight junctions, INADL_HUMAN.
Target Information: This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]