Description
Product Characteristics:
C3IP1
Subcellular location: Cytoplasm
Synonyms: C3IP1, CUL3 interacting protein 1, CUL3-interacting protein 1, DKIR, FLJ27152, Kelch like 12 (Drosophila), Kelch like 12, Kelch like 12 variant, Kelch like protein 12, kelch like protein C3IP1, Kelch-like protein 12, KLH12_HUMAN, KLHL 12, KLHL12, OTTHUMP00000038799.
Target Information: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity)