IL-17/IL-17A Antibody MAB317-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-17/IL-17A Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMAB317-100
Quantity100 ug (also 500 ug, 25 ug)
ApplicationsImmunohistochemistry, Immunoprecipitation, Neutralization, ELISA Capture (Matched Antibody Pair)
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityHuman, Primate
TargetIL-17/IL-17A
IsotypeIgG2b
Clone41809
HostMouse
ImmunogenE. coli-derived recombinant human IL-17, Ile20-Ala155, Accession # Q16552
NCBI Full Gene Nameinterleukin 17A
NCBI Gene AliasesIL-17A, ILA17, CTLA-8, CTLA8, IL17, IL-17
ClonalityMonoclonal
Brand/TrademarkR&D Systems, a Bio-Techne Brand
PurityProtein A or G purified from ascites
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects human and primate IL-17 in direct ELISAs. In direct ELISAs, approximately 12% cross-reactivity with recombinant canine IL-17 is observed and 25%-50% reactivity with recombinant human (rh) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant mouse IL-17, rhIL-17B, rhIL-17C, rhIL-17D, rhIL-17E, or rhIL-17F is observed

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Establishment of a humanized animal model of systemic sclerosis in which T helper-17 cells from patients with systemic sclerosis infiltrate and cause fibrosis in the lungs and skinExperimental & molecular medicineSeptember 1, 2022Park MJ, Park Y, Choi JW, Baek JA, Jeong HY, Na HS, Moon YM, Cho ML, Park SH.

(2) The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunityScientific reportsOctober 15, 2020Gorchs L, Ahmed S, Mayer C, Knauf A, Fernández Moro C, Svensson M, Heuchel R, Rangelova E, Bergman P, Kaipe H.

(3) T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal InflammationCell reportsJune 30, 2020Yan J, Pandey SP, Barnes BJ, Turner JR, Abraham C.

(4) A novel variant in AIRE causing a rare, non‑classical autoimmune polyendocrine syndrome type 1Molecular Medicine ReportsJune 12, 2020Wen‑Bin Zheng, Lu‑Jiao Li, Di‑Chen Zhao, Ou Wang, Yan Jiang, Wei‑Bo Xia, Mei Lierythropoietin (EPO; cat. no. DEP00) and antibodies to IFN-ω, IFN-α (cat. no. 21100-1), IL-17A (cat. no. MAB317-100), IL-17F (cat. no. MAB13353-100) and IL-22 (cat. no. MAB7822-100) were detected using ELISA kits (R&D Systems Inc

(5) Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axisNature communicationsFebruary 14, 2020Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, Jia S, Fox PL, Huang E, Pizarro TT, et al.

(6) Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin ModelsCellsSeptember 15, 2019Chamcheu JC, Esnault S, Adhami VM, Noll AL, Banang-Mbeumi S, Roy T, Singh SS, Huang S, Kousoulas KG, Mukhtar H.

(7) Serial Monitoring of Immune Markers Being Represented Regulatory T Cell/T Helper 17 Cell Ratio: Indicating Tolerance for Tapering Immunosuppression after Liver TransplantationFrontiers in immunologyJanuary 1, 2018Jhun J, Lee SH, Lee SK, Kim HY, Jung ES, Kim DG, Choi J, Bae SH, Yoon SK, Chung BH, et al.

(8) IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyJanuary 1, 2017Lv R, Zhao J, Lei M, Xiao D, Yu Y, Xie J.

(9) Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinomaPloS oneJanuary 1, 2017Brencicova E, Jagger AL, Evans HG, Georgouli M, Laios A, Attard Montalto S, Mehra G, Spencer J, Ahmed AA, Raju-Kankipati S, et al.

(10) Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritisArthritis research & therapyDecember 23, 2016Hull DN, Cooksley H, Chokshi S, Williams RO, Abraham S, Taylor PC.

(11) Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilageEuropean journal of immunologyFebruary 1, 2016Schminke B, Trautmann S, Mai B, Miosge N, Blaschke S.

(12) Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assaysCytokineDecember 1, 2013Todd J, Simpson P, Estis J, Torres V, Wub AH.

(13) TH17 cytokines induce human airway smooth muscle cell migrationThe Journal of allergy and clinical immunologyApril 1, 2011Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH.

(14) IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patientsImmunology lettersJanuary 4, 2010Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, et al.

(15) Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophilsThe Journal of investigative dermatologyMarch 1, 2009Rahmoun M, Molès JP, Pedretti N, Mathieu M, Fremaux I, Raison-Peyron N, Lecron JC, Yssel H, Pène J.

(16) Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytesJournal of immunology (Baltimore, Md. : 1950)March 1, 2009Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis MA, Miossec P.

(17) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activitiesJournal of immunology (Baltimore, Md. : 1950)September 15, 2008Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL.

(18) IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid bloodJournal of immunology (Baltimore, Md. : 1950)January 1, 2008Zrioual S, Toh ML, Tournadre A, Zhou Y, Cazalis MA, Pachot A, Miossec V, Miossec P.

(19) Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassaysJournal of immunological methodsJanuary 1, 2008Pfleger C, Schloot N, ter Veld F.

(20) Ultrasensitive flow-based immunoassays using single-molecule countingClinical chemistryNovember 1, 2007Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P.

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IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody

IL-17/IL-17A Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (22)

Reviews

IL-17/IL-17A Antibody from R&D Systems, a Bio-Techne Brand

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