BIOCARE MEDICAL's CD4 [4B12] Antibody is a Mouse monoclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
CD4 is a transmembrane glycoprotein, expressed on normal thymocytes, T-helper cells, the majority of mature peripheral T cells, and a subset of suppressor or cytotoxic T cells (1). Like many cell surface receptors/markers, CD4 is a member of the immunoglobulin superfamily. CD4 is expressed in the majority of T-cell lymphomas, including mycosis fungoides (2). CD4 has been used in lymphoma panels that include CD3, CD5, CD8, CD7 and TIA-1 (2-3). A panel consisting of CD4( ), CD2(-) and CD56( ) antibodies was also used to help identify agranular natural killer cell lymphoma of the skin (4). A CD4 assessment may be useful in HIV-infected individuals, as HIV infection depletes intestinal CD4( ) T cells and has a strong association with the level of systemic CD4( ) T cell activation (5). Tumor infiltrating CD4 T cells may also be a prognostic factor for the strategy of early antitumor immunity (6)