The WT1 Antibody (Center E361) from MyBioSource.com is a Rabbit Polyclonal antibody to AWT1, EWS-WT1, GUD, Wilms Tumor 1, and WT1. This antibody recognizes Human, Mouse, Rat, and Porcine antigen. The WT1 Antibody (Center E361) has been validated for the following applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
This gene encodes a transcription factor that contains
four zinc-finger motifs at the C-terminus and a
proline/glutamine-rich DNA-binding domain at the N-terminus. It has
an essential role in the normal development of the urogenital
system, and it is mutated in a small subset of patients with Wilm's
tumors. This gene exhibits complex tissue-specific and polymorphic
imprinting pattern, with biallelic, and monoallelic expression from
the maternal and paternal alleles in different tissues. Multiple
transcript variants have been described. In several variants, there
is evidence for the use of a non-AUG (CUG) translation initiation
site upstream of and in-frame with the first AUG. Authors of
PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA
editing in human and rat, and that this process is
tissue-restricted and developmentally regulated. [provided by
RefSeq]