Description
Product Characteristics: FUNCTION: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. SUBCELLULAR LOCATION: Cell membrane, Multi-pass membrane protein. Membrane, Multi-pass membrane protein. Note: Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons,SLC6 Family,Sodium- and chloride-dependent GABA transporter 1, GAT-1, Solute carrier family 6 member 1, GABATR, GABT1, GAT1
Target Information: The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]