Fig 1: Schematic diagram of an eMV including the proposed metabolic pathways according to the proteomic results. The blood plasma metabolites that can feed these routes and their plasma concentrations under control conditions are also included. 1,3BPG: 1,3-bisphosphoglycerate; 2PG: 2-phosphoglycerate; 3PG: 3-phosphoglycerate; 3PHP: 3-phosphohydroxypyruvate; 6PG: 6-phosphogluconate; 6PGL: 6-phosphoglucono-1,5-lactone; AKG: alpha-ketoglutarate; BCAA: branched-chain amino acids; DHAP: dihydroxyacetone 3-phosphate; F1,6BP: fructose 1,6-biphosphate; F6P: fructose 6-phosphate; G3P: glycerol 3-phosphate; G6P: glucose 6-phosphate; GADP: glyceraldehyde 3-phosphate; NAG: N-acetylglucosamine; NAG6P: N-acetylglucosamine-6-phosphate; OAA: oxaloacetate; PEP: phosphoenolpyruvate; P-Ser: phosphoserine; Ru5P: ribulose 5-phosphate.