Fig 1: Immunohistochemical detection of SPIN4. Representative images of nasopharyngeal carcinoma exhibiting lower SPIN4 immunoexpression (brown–orange) among (A) NPC patients with low-stage compared to that among (B) NPC patients with high-stage. Inset: adjacent non-neoplastic mucosa.
Fig 2: Survival analysis. Kaplan–Meier curves were plotted and revealed that (A–C) T3–T4 status, (D–F) N2–N3 status, and (G–I) AJCC stage III–IV tumors and (J–L) high SPIN4 expression in tumor specimens were all significantly correlated with poor DSS, DMeFS, and LRFS.
Fig 3: NGS data mining of genes associated with advanced nodal status in NPC. (A) The top 20 differentially expressed genes were examined by comparing tumor samples with a nodal status beyond or identical to N1 (N1+) to those with negative nodal status (N0). (B) Among these genes, SPIN4, with a prominent log2-transformed expression fold change, was selected for further analysis.
Supplier Page from Abcam for Anti-SPIN4 antibody