Fig 1: Gene expression analysis of TNBC PDX. (A) Classification of PDX according to Lehmann's classification of TNBC (N=57). BL1: Basal-like1; BL2: Basal-like 2; IM: Immuno-modulatory, M:Mesenchymal; MSL: Mesenchymal Stem Like; LAR: Luminal Androgen Receptor; UNS: Unstable); (B) RT-PCR expression analysis of AR- related genes (AR, FOXA1, XBP1, ABCC11) , EMT genes (SNAIL2, VIM, ACTA2, TCF7L2, CAV1) and cytokeratin's KRT5, KRT14, KRT18 in TNBC PDX (n=44). Fold changes and p value are calculated to analyze gene expression in LAR PDX as compared to the other TNBC subtypes.
Fig 2: Morphological and immunohistochemistry analysis of 3 LAR TNBC PDX. Representative hematoxylin-eosin (H&E) stained sections and expression of EGFR, CK5, CK14, CK8/18 and AR (20X).
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