Description
Product Characteristics: FUNCTION: Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation. Subcellular location: Nucleus,Epigenetics,SAGA associated factor 29 homolog, Coiled coil domain containing protein 101, CCDC101
Target Information: CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A\, MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H\, MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A\, MIM 602301)/PCAF (KAT2B\, MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]