Fig 1: Diagram of methionine/homocysteine metabolism. Reactions are shown as arrows in lines. Gene symbols for related enzymes are described in circles. Bhmt; betaine-homocysteine methyltransferase, Cbs; cystathionine beta-synthase, Dmgdh; dimethylglycine dehydrogenase, Gamt; guanidinoacetate methyltransferase, Gnmt; glycine N-methyltransferase, Ms; methionine synthase, Mthfr; methylenetetrahydrofolate reductase, Pcyt1a; phosphate cytidylyltransferase 1, Pemt; phosphatidylethanolamine N-methyltransferase, Sardh; sarcosine dehydrogenase.