Description
Product Characteristics:
Several proteins involved in regulating and executing programmed cell death have been identified in C. elegans. CED-3, a member of the ICE protease/caspase family, and CED-4, a homolog of the mammalian Apaf-1, promote apoptosis. CED-9, a homolog of the mammalian Bcl-2 protein, inhibits cell death. EGL-1 and CED-6 both function as death-promoting proteins, with CED-6 playing a role in the engulfment of apoptotic cells. CED-5 and CED-7 are C. elegans orthologs of the mammalian DOCK180 and ABC transporter proteins, respectively, and also play a role in the engulfment of dying cells.
Subcellular location: Cytoplasm
Synonyms: CED 6, Cell death protein 6 homolog, Engulfment adapter protein, Engulfment adaptor PTB domain containing 1, GULP, GULP, engulfment adaptor PTB domain containing 1, GULP1, GULP1_HUMAN, Protein GULP, PTB domain adapter protein CED 6, PTB domain adapter protein CED-6, PTB domain adaptor protein CED6, PTB domain-containing engulfment adapter protein 1.
Target Information: The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]