Description
Product Characteristics:
Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts.
Subcellular location: Nucleus
Synonyms: Neural-specic serine/arginine repetitive splicing factor of 100 kDa, Neural-specic SR-related protein of 100 kDa, nSR100, Serine/arginine repetitive matrix protein 4, Srrm4, SRRM4_HUMAN.
Target Information: SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]